منابع مشابه
Non-animal approaches for toxicokinetics in risk evaluations of food chemicals.
The objective of the present work was to review the availability and predictive value of non-animal toxicokinetic approaches and to evaluate their current use in European risk evaluations of food contaminants, additives and food contact materials, as well as pesticides and medicines. Results revealed little use of quantitative animal or human kinetic data in risk evaluations of food chemicals, ...
متن کاملIncorporating children's toxicokinetics into a risk framework.
Children's responses to environmental toxicants will be affected by the way in which their systems absorb, distribute, metabolize, and excrete chemicals. These toxicokinetic factors vary during development, from in utero where maternal and placental processes play a large role, to the neonate in which emerging metabolism and clearance pathways are key determinants. Toxicokinetic differences bet...
متن کاملTheophylline toxicokinetics in premature newborns.
BACKGROUND While cytochrome P4501A2 is the primary pathway for theophylline (aminophylline ethylenediamine) metabolism in adults, it is developmentally immature in the newborn. OBJECTIVE To report the developmental differences in theophylline toxicokinetics of neonates. DESIGN Case series. Three premature neonates received inadvertent intravenous overdoses of theophylline for apnea of prema...
متن کاملToxicokinetics and Metabolism
In this study, the dermal penetration rate of carbofuran, carbosulfan, and furathiocarb has been measured with rat abdominal skin using the static diffusion cell. The technical grades of three compounds were applied at different doses on skin surface mounted in static diffusion cell and incubated at 32 C for 48 h with shaking. The same procedures were carried out with furathiocarb EC (emulsifia...
متن کاملToxicokinetics of Kava
Kava is traditionally consumed by South Pacific islanders as a drink and became popular in Western society as a supplement for anxiety and insomnia. Kava extracts are generally well tolerated, but reports of hepatotoxicity necessitated an international reappraisal of its safety. Hepatotoxicity can occur as an acute, severe form or a chronic, mild form. Inflammation appears to be involved in bot...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2018
ISSN: 0893-228X,1520-5010
DOI: 10.1021/acs.chemrestox.8b00061